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Blood Purification for Kidney Disease

What is blood purification?

Blood purification refers to proper blood purification technique will be used according to the types of toxins in the body to help kidney disease patients clean the blood. The common types of blood purification techniques include hemodialysis, hemofiltration, hemoperfusion, immune adsorption, plasma exchange and CRRT.


Hemodialysis is the most common way to treat advanced, permanent kidney failure. The procedure can help you carry on an active life despite failing kidneys. Hemodialysis is a serious responsibility, but you don't have to shoulder it alone. You'll work closely with your health care team, which will include a kidney specialist and other professionals with experience managing hemodialysis.

-Remove small sized wastes in the blood, such as urea, creatinine, BUN, etc.

-Filter out the excess water from the body.

-Keep the balance of electrolytes in the blood.


Hemoperfusion is a treatment technique in which large volumes of the patient's blood are passed over an adsorbent substance in order to remove toxic substances from the blood. It is sometimes described as an extracorporeal form of treatment because the blood is pumped through a device outside the patient's body.

-Remove nephrotoxic drugs or poisons from the blood in emergency situations.

-Eliminate waste products from the blood in patients with chronic kidney disease.

-Compared with other treatment, it is more effective in eliminating some specific wastes in the blood, especially those bind to proteins in the body.


Hemofiltration is a therapy similar to hemodialysis, which is use to replace the function of kidneys in the case of kidney failure. Compared with hemodialysis, hemofiltration is always used in intensive care settings in case of acute renal failure.

-Remove the small and middle sized wastes in the blood, like chemicals, bilirubin and excessive vitamins.

-Eliminate a few of large sized toxins in the blood, such as cytokines and inflammatory mediators.

-Control the inflammations.

Immune adsorption

Immune adsorption is a therapy which uses adsorbing materials to alternatively or specifically remove the pathogenic factors related to immune system in the blood. It usually used in immune system diseases and liver diseases.

-Remove the large-molecule toxins in the blood, such as immunoglobulin, immune complexes, albumin, endotoxin, cytokines and inflammatory mediators.

-Remove antigen by specific antiserum in a similar manner.

-Remove the antibody from antiserum by use of specific antigen.

-Taking effect quickly.

Plasma exchange

Plasma exchange is done to exchange plasma in the blood. Once the plasma is removed, fresh plasma or plasma substitute is added back to the blood. It shows promising effects in treating the following kidney diseases: anti-glomerular basement membrane disease, Acute Glomerulonephritis, serious Focal Segmental Glomerulonephritis, Lupus Nephritis, crescent Glomerulonephritis, immune kidney disease, lipoprotein glomerulopathy etc.

-Clearing of circulating harmful components like protein bound toxics, monoclonal gammaglobulins, circulating immune complexes.

-Vascular rheologic parameters improvement, particularly aimed in vasculitis and microcirculation impairment.

-By removing antibodies PE could amplify their secreting cells sensitivity to immunosuppression drugs.

-Clearing properties of PE relieve the macrophagic system cells in dysimmune disease, hitherto increasing their ability to remove immunoglobulin and immune complexes.

-Globally PE clear plasma protein or protein bound toxics and generate quick immunosuppression.


CRRT is intended to run for 24 hours a day, but the average therapy time is actually closer to 16 hours a day due to interruption. It deals with all sized waste molecules in the blood. If your patient is critically ill with acute kidney injury (AKI), CRRT is one of the primary therapies. The goal of any continuous renal replacement therapy (CRRT) is to replace, as best as possible, the lost function of kidneys. CRRT provides slow and balanced fluid removal that even unstable patients - those with shock or severe fluid overload - can more easily tolerate. Both average and smaller size patients can undergo CRRT therapy and it can be adapted quickly to meet changing needs.

-Reduce clotting in the hemofilter to maximize the CRRT circuit life.

- Replace the excretory function of the kidney.

- Deals with acute renal failure, chronic renal failure, fluid overload, drug overdose, life-threatening electrolyte imbalance, major burns with compromised renal function.

- Remove fluid in special circumstances—post surgery pulmonary edema, ARDS etc.

- Provide excellent control of azotemia, electrolytes and acid base balance. - Remove proinflammtory medicators of inflammation, such as IL-1, IL-6, IL-8, TNF-a.

Are there any side effects?

Yes, there are. Let’s take dialysis for an example. The side effects can include low blood pressure, itching, headaches, leg cramps, fever, chest pain, nausea, vomiting, sleep problems, fatigue, etc.

No one wants to experience dialysis, which is a fact. But sometimes dialysis can be very necessary. An efficient treatment which can recover kidney function is needed if patients want to avoid or get rid of dialysis.

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